Endocrine Abstracts

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different publish...

Background: The aim of this study was to evaluate the outcomes of medical treatment in patients with active acromegaly.Material and Methods: We performed a retrospective analysis of 163 patients (101 female, age at diagnosis 47.2±13.4 years) treated between 1990 and 2020., of which 53 were on medical treatment (32.5%). Remission rate after pituitary surgery was 66.5% (n=105/158; 5 patients refused surgery). Patients who did not achieve remiss...

Background: Laparoscopic adrenalectomy (LA) is the standard treatment for benign adrenal tumours but its role in the surgical management of adrenocortical carcinoma (ACC) is controversial. Therefore, the aim of this study was to compare long-term outcome between open adrenalectomy (OA) and LA in the treatment of primary ACC.Methods: This retrospective cohort study included patients with ACC ENSAT stage I-III referred to the Croatian referral centre for a...